Endocrine Abstracts

Introduction: Abnormalities in the development and migration of the thyroid gland are known to produce ectopic thyroid tissue, usually in the midline between the tongue base and the diaphragm. Hashimoto’s thyroiditis involving ectopic thyroid tissue is particularly unusual. Herein we report a case of Hashimoto’s thyroiditis developing in a midline thyroid cervical mass.Observation: A 55-year-old man was referred for hypothyroidism. His physical...

Introduction: Systemic amyloidosis leads to functional compromise of various organs through infiltration of these tissues by amyloid protein.The aim of this study was to determine the endocrine disorders in patients with systemic amyloidosis.Methods: During the period from 1975 to 2006, we collected 580 patients with renal amyloidosis confirmed by histological exam. We selected 123 patients with hormonal exploration. 55 patients ha...

Introduction: Steroid 11β-hydroxylase deficiency (11-OHD) is the second most common causeof congenital adrenal hyperplasia (CAH),characterized by the overproduction of adrenal androgens and deoxycorticosterone (DOC).It usually presents with virilization of the female fetus, precocious puberty in male infants and hypertension with or without hypokalemia in both genders. Because of high levels of mineralocorticoids, patients rarely present with salt wasting (SW). We herein ...

Introduction: Severe hypercalcemia is a life-threatening condition which should be managed urgently. Its pharmacological treatment consists of intravenous saline hydration, loop diuretic and intravenous administration of bisphosphonates. However, data evaluating these treatments are very limited.The aim of this study was to assess the efficiency of saline hydration, furosemide, and bisphosphonates in the management of severe hypercalcemia secondary to a ...

Introduction: Primary adrenal insufficiency is a classically rare but potentially serious disease due to the risk of acute adrenal crisis. Although autoimmune origin is the first etiology in adults, genetic causes are most common in children.Herein, we reporta case of coexisting hypogonadotropic hypogonadism and growth hormone (GH) deficiency in a patient with Addison’s disease.Observation: A 15-year-old boy was referred to o...

Introduction: Hyponatremia represents a frequent electrolyte disorder. It is defined as a serum sodium level below 135 mmol/L and it is severe when serum level is below 125 mmol/l. Endocrine disorders including adrenal deficiency and hypothyroidism are uncommon causes of hyponatremia. Secondary adrenal insufficiency is related with hyponatremia through increased ADH secretion.Herein, we report a case of severe hyponatremia revealing hypopituitarism.<...

Introduction: Adrenocortical carcinoma (ACC) is a rare aggressive endocrine neoplasm. It’s a heterogeneous malignant tumor with incompletely understood pathogenesis and poor prognosis. The aim of our study was to assess clinical and paraclinical characteristics of ACC and to determine its outcome.Methods: In a retrospective and descriptive study, we included patients with adrenocortical carcinoma confirmed with histopathological examination. Clinic...

Introduction: Fasting the month of Ramadan is practiced by more than one billion Muslims worldwide, including type 2 diabetic patients. Its effects on body composition and body weight in type 2 diabetic patients are controversial.The objective of our study was to assess the evolution of anthropometric parameters as well as the body composition in type 2 diabetic patients who fasted the month of Ramadan.Methods: We conducted a prosp...

Introduction: Hypoglycemia is common in diabetic patients as an adverse effect of their medication. A minority of hypoglycemia occurs in non-diabetic patients. This spontaneous hypoglycemia defined by the Whipple’s triad results from organic (non-reactive) or functional (reactive) causes, and in few cases, a factitious hypoglycemia, posing an etiological problem. The aim of our study was to assess clinical and biological features of non-reactive hypoglycemia in non-diabe...

Introduction: CD8+ T-cell deficiency is a feature of many chronic autoimmune diseases. Its association with vitamin D deficiency was described and it has been suggested that vitamin d deficiency contribute to the increase of the incidence and the progression of autoimmune diseases.Herein we report a case of hypopituitarism and vitamin D deficiency in a patient with CD8+ T-cell deficiency.Observation: A 28-year-old woman was...